Idiopathic pulmonary fibrosis (IPF) is the most common form of lung disease with unknown etiology that causes scarring and stiffness in the tissue. The disease represents 50% 3-5-year survival post-diagnosis. Mounting evidence indicates that oxidative stress is a significant player in the pathogenesis of IPF. Oxidative stress is characterized by an increase in the production of reactive oxygen species (ROS) sourced predominantly from NADPH oxidases (NOXes) and mitochondria. Several Studies have unveiled the role of NOXes esp NOX1, NOX2 and NOX4 in the IPF pathogenesis in addition to the role of mitochondrial ROS. Among the other NOX-isoforms, NOX4 is particularly noted for its inducibility by transforming growth factor-beta (TGF-β, known for its high levels in IPF) and its ability to generate H2O2 after induction.